Decreased CD4:CD8 ratio
Basic details
Preferred term: Decreased CD4:CD8 ratio
Alt. terms: Inverted CD4/CD8 ratio | Inverted CD4:CD8 ratio
HPO term: Decreased CD4:CD8 ratio
HPO code: HP:0033222
GenIA ID: 13485
Last updated on: 2021-08-02 21:50:33
Cross ref. with other ontologies
NCIT: -
MESH: -
EFO: -
OAE: -
SNOMEDCT: -
ICD10: -
Description
An abnormal reduction of the relative proportion of CD4+ to CD8+ T cells. Note: A low or inverted CD4/CD8 ratio is an immune risk phenotype and is associated with altered immune function, immune senescence, and chronic inflammation in both HIV-infected and uninfected populations.
Hierarchical classification
Reported patients added to GenIA DB
SubjectID | Sex | Fam.ID | Age* | Population | MatchedTerm | Diagnosis | Reference & Pub.codes |
---|---|---|---|---|---|---|---|
105088 | M | 215638 | 35 | Japanese | Abnormal CD4:CD8 ratio | CTLA4 haploinsufficiency with autoimmune infiltration | PMID:26644313 [II.3(II.3)]; PMID:30250467 [M.II.3]; PMID:29729943 [Fam.M:II.3(M.II.3 (37))]; PMID:27418640 [P21(II.3)]; PMID:35087518 [11.1] |
105542 | M | 215796 | - | Decreased CD4:CD8 ratio | CTLA4 haploinsufficiency with autoimmune infiltration | PMID:28983403 [P6] | |
106840 | M | 216167 | - | SouthEast Asian | Decreased CD4:CD8 ratio | CTLA4 haploinsufficiency with autoimmune infiltration | PMID:35242131 [3] |
*Age: age reported at the first known time of manifestation; PMID: PubMed ID; GRID: GenIA reference ID (ref. not in PubMed).