Impaired lymphocyte transformation with phytohemagglutinin
Basic details
Preferred term: Impaired lymphocyte transformation with phytohemagglutinin
Alt. terms:
HPO term: Impaired lymphocyte transformation with phytohemagglutinin
HPO code: HP:0003347
GenIA ID: 3051
Last updated on: 2021-08-02 21:50:33
Cross ref. with other ontologies
NCIT: -
MESH: -
EFO: -
OAE: -
SNOMEDCT: -
ICD10: -
Description
Normal peripheral blood lymphocytes, when stimulated by phytohemagglutinin (PHA) are cytotoxic for homologous and heterologous cells but not for autologous cells in monolayer culture. The cytotoxic effect is thought to be indicative of the immunological competence of the lymphocytes. Note: The response of lymphocytes to PHA is measured by their ability to transform and to undergo mitosis.
Hierarchical classification
PARENT terms
TERM
Impaired lymphocyte transformation with phytohemagglutinin
CHILD terms
Reported patients added to GenIA DB
SubjectID | Sex | Fam.ID | Age* | Population | MatchedTerm | Diagnosis | Reference & Pub.codes |
---|---|---|---|---|---|---|---|
106390 | M | 216005 | - | Impaired lymphocyte transformation with phytohemagglutinin | CTLA4 haploinsufficiency with autoimmune infiltration | PMID:32996901 [Patient(II.1)] |
*Age: age reported at the first known time of manifestation; PMID: PubMed ID; GRID: GenIA reference ID (ref. not in PubMed).