Diffuse alveolar hemorrhage

Basic details

Preferred term: Diffuse alveolar hemorrhage
Alt. terms: Diffuse alveolar haemorrhage

HPO term: Diffuse alveolar hemorrhage
HPO code: HP:0025420

GenIA ID: 610
Last updated on: 2024-04-25 14:48:58

Cross ref. with other ontologies

NCIT: -
MESH: -
EFO: -
OAE: -
SNOMEDCT: -
ICD10: -

Description

A type of of pulmonary hemorrhage that originates from the pulmonary microcirculation, including the alveolar capillaries, arterioles, and venules. It presents with hemoptysis, anemia, diffuse lung infiltration, and acute respiratory failure. The diagnosis is confirmed by the observation of the accumulation of red blood cells, fibrin, or hemosiderin-laden macrophage in the alveolar space on pathologic biopsy. Hemosiderin, a product of hemoglobin degradation, appears at least 48-72 hours after bleeding and is helpful in distinguishing diffuse alveolar hemorrhage from surgical trauma. Mild interstitial thickening, organizing pneumonia, or diffuse alveolar damage can also be seen. Diffuse alveolar hemorrhage is a life-threatening and medical emergency that can be caused by numerous disorders and presents with hemoptysis, anemia, and diffuse alveolar infiltrates.

Hierarchical classification

PARENT terms
TERM

Diffuse alveolar hemorrhage

CHILD terms

Reported patients added to GenIA DB

SubjectID Sex Fam.ID Age* Population MatchedTerm Diagnosis Reference & Pub.codes
101091 M 210911 17 Diffuse alveolar hemorrhage DiGeorge syndrome PMID:34975878 [Fam.F057:P057]; PMID:35486341 [P180]
105343 F 215705 2 Finnish Diffuse alveolar hemorrhage Early-onset pulmonary and cutaneous vasculitis PMID:34536415 [P1(I.1)]
106957 F 216198 - Pulmonary hemorrhage Infantile-Onset Multisystem Autoimmune Disease 1 PMID:30092289 [P13]
106959 M 216200 - Pulmonary hemorrhage Infantile-Onset Multisystem Autoimmune Disease 1 PMID:30092289 [P17]; PMID:35677041 [Pt9]

*Age: age reported at the first known time of manifestation; PMID: PubMed ID; GRID: GenIA reference ID (ref. not in PubMed).