Diffuse alveolar hemorrhage
Basic details
Preferred term: Diffuse alveolar hemorrhage
Alt. terms: Diffuse alveolar haemorrhage
HPO term: Diffuse alveolar hemorrhage
HPO code: HP:0025420
GenIA ID: 610
Last updated on: 2024-04-25 14:48:58
Cross ref. with other ontologies
NCIT: -
MESH: -
EFO: -
OAE: -
SNOMEDCT: -
ICD10: -
Description
A type of of pulmonary hemorrhage that originates from the pulmonary microcirculation, including the alveolar capillaries, arterioles, and venules. It presents with hemoptysis, anemia, diffuse lung infiltration, and acute respiratory failure. The diagnosis is confirmed by the observation of the accumulation of red blood cells, fibrin, or hemosiderin-laden macrophage in the alveolar space on pathologic biopsy. Hemosiderin, a product of hemoglobin degradation, appears at least 48-72 hours after bleeding and is helpful in distinguishing diffuse alveolar hemorrhage from surgical trauma. Mild interstitial thickening, organizing pneumonia, or diffuse alveolar damage can also be seen. Diffuse alveolar hemorrhage is a life-threatening and medical emergency that can be caused by numerous disorders and presents with hemoptysis, anemia, and diffuse alveolar infiltrates.
Hierarchical classification
Reported patients added to GenIA DB
SubjectID | Sex | Fam.ID | Age* | Population | MatchedTerm | Diagnosis | Reference & Pub.codes |
---|---|---|---|---|---|---|---|
101091 | M | 210911 | 17 | Diffuse alveolar hemorrhage | DiGeorge syndrome | PMID:34975878 [Fam.F057:P057]; PMID:35486341 [P180] | |
105343 | F | 215705 | 2 | Finnish | Diffuse alveolar hemorrhage | Early-onset pulmonary and cutaneous vasculitis | PMID:34536415 [P1(I.1)] |
106957 | F | 216198 | - | Pulmonary hemorrhage | Infantile-Onset Multisystem Autoimmune Disease 1 | PMID:30092289 [P13] | |
106959 | M | 216200 | - | Pulmonary hemorrhage | Infantile-Onset Multisystem Autoimmune Disease 1 | PMID:30092289 [P17]; PMID:35677041 [Pt9] |
*Age: age reported at the first known time of manifestation; PMID: PubMed ID; GRID: GenIA reference ID (ref. not in PubMed).