Impaired oxidative burst

Basic details

Preferred term: Impaired oxidative burst
Alt. terms: Negative NBT reduction test | Negative nitroblue tetrazolium reduction test

HPO term: Impaired oxidative burst
HPO code: HP:0003203

GenIA ID: 754
Last updated on: 2024-04-25 14:48:58

Cross ref. with other ontologies

NCIT: -
MESH: -
EFO: -
OAE: -
SNOMEDCT: -
ICD10: -

Description

In the NBT test, neutrophils change the colorless compound NBT into a compound with a deep blue color. If this test is negative (i.e., no blue color is produced), then this indicates a defect in superoxide-generating NADPH oxidase activity with inability to efficiently kill phagocytized bacteria. The NBT test measures the ability of neutrophils to convert nitroblue tetrazolium (NBT), to a deep blue color. This test can be abnormal in chronic granulomatous disease.

Hierarchical classification

TERM

Impaired oxidative burst

CHILD terms

Reported patients added to GenIA DB

SubjectID Sex Fam.ID Age* Population MatchedTerm Diagnosis Reference & Pub.codes

*Age: age reported at the first known time of manifestation; PMID: PubMed ID; GRID: GenIA reference ID (ref. not in PubMed).