Impaired oxidative burst
Basic details
Preferred term: Impaired oxidative burst
Alt. terms: Negative NBT reduction test | Negative nitroblue tetrazolium reduction test
HPO term: Impaired oxidative burst
HPO code: HP:0003203
GenIA ID: 754
Last updated on: 2024-04-25 14:48:58
Cross ref. with other ontologies
NCIT: -
MESH: -
EFO: -
OAE: -
SNOMEDCT: -
ICD10: -
Description
In the NBT test, neutrophils change the colorless compound NBT into a compound with a deep blue color. If this test is negative (i.e., no blue color is produced), then this indicates a defect in superoxide-generating NADPH oxidase activity with inability to efficiently kill phagocytized bacteria. The NBT test measures the ability of neutrophils to convert nitroblue tetrazolium (NBT), to a deep blue color. This test can be abnormal in chronic granulomatous disease.
Hierarchical classification
TERM
Impaired oxidative burst
CHILD terms
Reported patients added to GenIA DB
SubjectID | Sex | Fam.ID | Age* | Population | MatchedTerm | Diagnosis | Reference & Pub.codes |
---|
*Age: age reported at the first known time of manifestation; PMID: PubMed ID; GRID: GenIA reference ID (ref. not in PubMed).