Hemophagocytosis

Basic details

Preferred term: Hemophagocytosis
Alt. terms:

HPO term: Hemophagocytosis
HPO code: HP:0012156

GenIA ID: 9046
Last updated on: 2021-08-02 21:50:33

Cross ref. with other ontologies

NCIT: -
MESH: -
EFO: -
OAE: -
SNOMEDCT: -
ICD10: -

Description

Phagocytosis by macrophages of erythrocytes, leukocytes, platelets, and their precursors in bone marrow and other tissues. Note: Hemophagocytosis is a nonspecific phenotypic feature observed in several conditions including hemolytic anemia, malignant disease, infections, and hemophagocytic syndrome (also known as hemophagocytic lymphohistiocytosis, a rare hyperinflammatory syndrome caused by severe hypercytokinemia due to a highly stimulated but ineffective immune process).

Hierarchical classification

Reported patients added to GenIA DB

SubjectID Sex Fam.ID Age* Population MatchedTerm Diagnosis Reference & Pub.codes
102626 M 214969tree icon - Filipino Hemophagocytosis Immunodeficiency 98 with autoinflammation, somatic PMID:33512449 [Fam.1:II.1(P1)]
102987 F 215075tree icon 14 Austrian Hemophagocytosis Immunodeficiency 97 PMID:33054089 [Patient(II.1)]
103454 M 215130tree icon 7 Saudi Hemophagocytosis infantile-onset multisystem autoimmune disease-3 PMID:36006710 [Fam.2:II.2(P2)]
103485 F 215137tree icon 10 French Hemophagocytosis Immunodeficiency 55 PMID:28414293 [Fam.D:II.1(P5)]
105103 F 215641 11 South Korean Hemophagocytosis CTLA4 haploinsufficiency with autoimmune infiltration PMID:26478010 [III.2(III.2)]

*Age: age reported at the first known time of manifestation; PMID: PubMed ID; GRID: GenIA reference ID (ref. not in PubMed).