Squamous cell carcinoma
Basic details
Preferred term: Squamous cell carcinoma
Alt. terms: Squamous cell cancer | Epidermoid Carcinoma
HPO term: Squamous cell carcinoma
HPO code: HP:0002860
GenIA ID: 916
Last updated on: 2021-12-06 09:20:57
Cross ref. with other ontologies
NCIT: C2929
MESH: D002294
EFO:0000707
OAE: -
SNOMEDCT: -
ICD10: -
Description
A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma.
Hierarchical classification
PARENT terms
TERM
Squamous cell carcinoma
Reported patients added to GenIA DB
| SubjectID | Sex | Fam.ID | Age* | Population | MatchedTerm | Diagnosis | Reference & Pub.codes |
|---|---|---|---|---|---|---|---|
| 101153 | M | 210757 | 38 | German | Neoplasm of the skin | Hyper-IgE recurrent infection syndrome 2 | PMID:34390440 [HIES55] |
| 101183 | F | 210282 |
34 | German | Squamous cell carcinoma of the vulva | Immunodeficiency, common variable, 1 | PMID:12577056 [Fam.A:II.1(P1)]; PMID:16384931 [Fam.A:II.2(P1)]; PMID:19426217 [Fam.A:II.1(P1)]; PMID:28861081 [Fam.1:II.1(P1)] |
| 101365 | M | 212160 | - | North American | Squamous cell carcinoma | Immunodeficiency, common variable, 8 | PMID:27379089 [P14] |
| 101767 | F | 210788 | 47 | Neoplasm of the skin | PMID:34975878 [Fam.F249:P249] | ||
| 101915 | F | 211935 | - | Squamous cell carcinoma of the vulva | CTLA4 haploinsufficiency with autoimmune infiltration | PMID:34975878 [Fam.F341:P341] | |
| 104268 | M | 215444 |
- | Ashkenazi Jewish | Squamous cell carcinoma | Infantile-Onset Multisystem Autoimmune Disease 1 | PMID:28153428 [Patient(II.2)] |
| 104953 | F | 215622 |
- | Dutch | Squamous cell carcinoma | NFKB1 insufficiency | PMID:32278790 [Fam.NA:II.14(II.14)]; PMID:26279205 [Fam.NL1:II.18(16)]; PMID:29403474 [Fam.NL1 (5):II.18(16)]; PMID:11583829 [Fam.1:II.17(II:17)]; PMID:16639407 [Fam.1:II.18(16)]; PMID:150198 [Fam.AA:II.18(020)] |
| 106718 | M | 216119 |
- | Chinese (China) | Squamous cell carcinoma of the skin | Immunodeficiency 22 | PMID:27087313 [Fam.1:V.2(P2)] |
| 106719 | F | 216119 |
- | Chinese (China) | Squamous cell carcinoma of the skin | Immunodeficiency 22 | PMID:27087313 [Fam.1:V.3(P3)] |
*Age: age reported at the first known time of manifestation; PMID: PubMed ID; GRID: GenIA reference ID (ref. not in PubMed).