Information on AGM6

Basic details

Name: Agammaglobulinemia 6 | Acronym: AGM6
Alt. names: CD79B deficiency

Gene: CD79B | MOI: Autosomal recessive | Mechanism of action:

No. of cases in DB: 0 | First reported in: 2007

Last updated on: 2023-02-28 16:41:18 by

Orphanet: -

MONDO: -

DOID: -

ClinGen:

An autosomal recessive form of agammaglobulinemia caused by mutations in the gene CD79B.

Antiinfectious prophylaxis and early and aggressive treatment of infections may be beneficial.

Please mind that full curation of this condition has not started yet. Please contact us if you want to volunteer.

SubjectID	Sex	Fam.ID	AD	AFM	Validity	Country	Population	Reference & Pub.code

AD: Age at genetic diagnosis; AFM: age at first manifestation; PMID: PubMed ID; GRID: GenIA reference ID (ref. not in PubMed).

[Considering only Definitive and Possible cases]

Rank	Clinical term	Present	Unreported
1	Reduced number of B cells	2 (99.9%)	0 (0.0%)
2	Decreased IgA levels	2 (99.9%)	0 (0.0%)
3	Decreased IgG levels	2 (99.9%)	0 (0.0%)
4	Decreased IgM levels	2 (99.9%)	0 (0.0%)
5	Infantile onset	2 (99.9%)	0 (0.0%)
6	Recurrent bronchitis	2 (99.9%)	0 (0.0%)
7	Chronic sinusitis	1 (99.9%)	0 (0.0%)
8	Conjunctivitis	1 (99.9%)	0 (0.0%)
9	Diarrhea	1 (99.9%)	0 (0.0%)
10	repeated bacterial infections	1 (99.9%)	0 (0.0%)
11	Recurrent otitis media	1 (99.9%)	0 (0.0%)
12	Recurrent pneumonia	1 (99.9%)	0 (0.0%)
13	Abnormal T cell morphology	0 (0.0%)	1 (99.9%)

Please mind that full curation of this condition has not started yet. Please contact us if you want to volunteer.

[Considering only Definitive and Possible cases]

Treatment ⓘ	Responses & clinical indications

Please mind that full curation of this condition has not started yet. Please contact us if you want to volunteer.