Name: Mycobacterium tuberculosis, susceptibility to, 4 | Acronym: TBS4
Alt. names:

Gene: CISH | MOI: Autosomal inheritance | Mechanism of action:

No. of cases in DB: 0 | First reported in: 2010

Last updated on: 2023-02-28 16:41:18 by Andrés Caballero-Oteyza

OMIM: 607948

Orphanet: -

MONDO: -

DOID: -

ClinGen:

Mycobacterium tuberculosis latently infects approximately one-third of humanity and is comparable only to human immunodeficiency virus as a leading infectious cause of mortality worldwide. Obstacles for controlling TB infection include lengthy treatment regimens of 6 to 9 months, drug resistance, lack of a highly efficacious vaccine, and incomplete understanding of the factors that control infectivity and disease progression. Although only 10% of individuals infected with M. tuberculosis develop active disease, the immune responses associated with TB susceptibility or resistance are not known. In addition, it is not known why some individuals have disseminated TB that spreads to the meninges and central nervous system, while most people have localized disease in the lungs. A number of studies suggest that host genetic factors influence susceptibility and resistance to TB (review by Berrington and Hawn, 2007).[OMIM]

Description of management option has not been reviewed yet.