Alt. symbols: IL-23R

Approved name: interleukin 23 receptor
Alt. names: interleukin23 receptor | IL23 receptor

Location: 1p31.3: 67138907 - 67259979 (+)
Gene type: protein_coding, 33 transcripts.

Scores: LoFtool: 0.367000 | pLI: 0.00649530 | LOEUF: 0.606

HGNC: 19100

NCBI: 149233, RefSeq: NG_011498.1

Ensembl: ENSG00000162594.17

LRG_ | Status: none

OMIM: 607562

Expression | ProteinAtlas

Gene Ontology (GO)

• Molecular function: cytokine receptor activity [GO:0004896]; interleukin-12 receptor binding [GO:0005143]; interleukin-23 binding [GO:0042019]; cytokine binding [GO:0019955]
• Cell component: interleukin-23 receptor complex [GO:0072536]; external side of plasma membrane [GO:0009897]
• Biological process: cytokine-mediated signaling pathway [GO:0019221]

Normal function

The IL23R gene encodes the interleukin 23 (IL-23) receptor. This protein is embedded in the outer membrane of several types of immune system cells, including T cells, natural killer (NK) cells, monocytes, and dendritic cells. At the cell surface, the IL-23 receptor interacts with the cytokine IL-23. When IL-23 binds to its receptor, it triggers a series of chemical signals inside the cell that promote inflammation and help coordinate the immune system's response to foreign pathogens. IL23 is a heterodimeric cytokine consisting of p19 (IL23A) and p40 (IL12B) subunits. The p40 subunit also interacts with p35 (IL12A) to form IL12. IL23, like IL12, bind to IL12RB1, but only IL12 binds to IL12RB2. IL23R does not interact with IL12, but pairs with IL12RB1 to confer IL23 responsiveness on cells expressing both subunits (Parham et al., 2002).

Dysfunction and disease

Single nucleotide polymorphisms in IL23R have been associated, among others, with protection or susceptibility to develop Crohn's disease {Inflammatory bowel disease 17, protection against} [MIM:612261], with decreased risk of developing gastric cancer or with increased protection for the development of psoriasis [MIM:605606]. [Load More]