Alt. symbols: N-ras

Approved name: NRAS proto-oncogene, GTPase
Alt. names: neuroblastoma RAS viral (v-ras) oncogene homolog, neuroblastoma RAS viral oncogene homolog

Location: 1p13.2: 114704469 - 114716771 (-)
Gene type: protein_coding, 1 transcripts.

Scores: LoFtool: | pLI: 0.91277290 | LOEUF: 0.612

HGNC: 7989

NCBI: 4893, RefSeq: NG_007572.1

Ensembl: ENSG00000213281.5

LRG_92 | Status: public

OMIM: 164790

Expression | ProteinAtlas

The NRAS gene encodes a protein called N-Ras that is primarily involved in regulating cell division. Through signal transduction, the protein relays proliferative or maturation signals from outside the cell to the cell's nucleus, so that the cells can grow and divide, maturate, or differentiate. The N-Ras protein is a GTPase, which means it converts GTP into GDP, and acts like a switch, being turned on and off by the GTP and GDP molecules. To transmit signals, the N-Ras protein must be turned on (bound to GTP). The N-Ras protein is turned off (inactivated) when it converts the GTP to GDP. When the protein is bound to GDP, it does not relay signals to the cell's nucleus. NRAS belongs to the group of oncogenes, which when mutated, have the potential to cause normal cells to become cancerous. Specifically, NRAS belongs to the Ras family of oncogenes, which also includes HRAS and KRAS. The proteins produced from these three genes are GTPases. These proteins play important roles in cell division, cell differentiation, and apoptosis.

Germline heterozygous mutations in this gene have been associated with Noonan syndrome type 6 [MIM:613224]. However, somatic mutations have been associated with autoimmune lymphoproliferative syndrome, Epidermal nevus, Giant congenital melanocytic nevus and with many types of cancers, including melanomas, lung cancers, cholangiocarcinomas, and acute myeloid leukemias. [Load More]