Information on RHOG
Alt. symbols: ARHG | MGC125835 | MGC125836
Approved name: ras homolog family member G
Alt. names: ras homolog gene family, member G (rho G)
Location: 11p15.4: 3826978 - 3840959 (-)
Gene type: protein_coding, 4 transcripts.
Scores: LoFtool: 0.087800 | pLI: 0.60068284 | LOEUF: 0.887
Gene Ontology (GO)
- Molecular function: GTP binding [GO:0005525]; protein kinase binding [GO:0019901]; GTPase activity [GO:0003924]
- Cell component: cell cortex [GO:0005938]; cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; cell projection [GO:0042995]; cytoskeleton [GO:0005856]
- Biological process: motor neuron axon guidance [GO:0008045]; cell projection assembly [GO:0030031]; Rac protein signal transduction [GO:0016601]; actin filament organization [GO:0007015]; engulfment of apoptotic cell [GO:0043652]; cortical cytoskeleton organization [GO:0030865]; regulation of cell shape [GO:0008360]; establishment or maintenance of cell polarity [GO:0007163]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of neutrophil migration [GO:1902622]
Normal function
Dysfunction and disease
[Load More]
[Gene NOT reviewed yet]
Associated conditions
| Acronym | Condition's_name | MOI | Mode_of_action |
OMIM_ID | No.cases |
|---|---|---|---|---|---|
FHL8 |
Hemophagocytic lymphohistiocytosis, familial, 8 | AR |
- | 0 (0 fams) |
Please mind that curation (inclusion of all reported patients) of this gene has not started yet. Please contact us if you want to volunteer.
Transcripts of RHOG
| Name | ENSEMBL_ID | LRG_ID | CCDS_ID | MANE | Transcript.type | Exons | Canonical | CDS_length | REFSEQ_ID |
|---|---|---|---|---|---|---|---|---|---|
| 202 | ENST00000396978.1 | CCDS7748 | protein_coding | No | 1066 | XM_005252916 | |||
| 201 | ENST00000351018.5 | CCDS7748 | Select | protein_coding | Yes | 1295 | NM_001665 |
Published variants
Found 0 variants
| Var.name ⓘ | Exon/Intron | cDNA_pos. | CDS_change | Prot.change | Var.type | Var.class. | Patients |
|---|
Please mind that curation (inclusion of all reported gene variants) has not started yet. Please contact us if you want to volunteer.
Diagnostic pitfalls & paradigms
Considerations to take into account when analyzing this gene
| Year | Paradigm ⓘ | PMID | Notes |
|---|---|---|---|
| - | Regions of Homology | - | |
| - | Cryptic splicing | - | Unreported or not recorded in our DB. |
| - | Uniparental disomy | - | Unreported or not recorded in our DB. |
| - | Mosaicism | - | Unreported or not recorded in our DB. |
| - | Incomplete penetrance | - | Unreported or not recorded in our DB. |
| - | Di-/oligo-genic inheritance | - | Unreported or not recorded in our DB. |
| - | Somatic reversion | - | Unreported or not recorded in our DB. |
References linked to variants in RHOG
Please mind that curation (inclusion of all relevant literature) has not started yet. Please contact us if you want to volunteer.
| ID | Year | Title | Journal | PMID | Variants |
|---|