Information on FPR1
Alt. symbols: FPR | FMLP
Approved name: formyl peptide receptor 1
Alt. names: fMetLeuPhe receptor | Nformylpeptide chemoattractant receptor | fMLP receptor
Location: 19q13.41: 51745172 - 51804115 (-)
Gene type: protein_coding, 4 transcripts.
Scores: LoFtool: 0.570000 | pLI: 0.06380581 | LOEUF: 0.000
Gene Ontology (GO)
- Molecular function: N-formyl peptide receptor activity [GO:0004982]; complement receptor activity [GO:0004875]
- Cell component: plasma membrane [GO:0005886]
- Biological process: inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; complement receptor mediated signaling pathway [GO:0002430]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]
Normal function
Dysfunction and disease
[Load More]
[Gene NOT reviewed yet]
Associated conditions
| Acronym | Condition's_name | MOI | Mode_of_action |
OMIM_ID | No.cases |
|---|---|---|---|---|---|
AgPS |
Susceptibility to aggresive periodontitis | AR |
- | 0 (0 fams) |
Please mind that curation (inclusion of all reported patients) of this gene has not started yet. Please contact us if you want to volunteer.
Transcripts of FPR1
| Name | ENSEMBL_ID | LRG_ID | CCDS_ID | MANE | Transcript.type | Exons | Canonical | CDS_length | REFSEQ_ID |
|---|---|---|---|---|---|---|---|---|---|
| 203 | ENST00000595042.5 | CCDS12839 | protein_coding | 3 | No | 1965 | NM_001193306 | ||
| 201 | ENST00000304748.5 | 1 | CCDS12839 | Select | protein_coding | 2 | Yes | 1298 | NM_002029 |
Published variants
Found 0 variants
| Var.name ⓘ | Exon/Intron | cDNA_pos. | CDS_change | Prot.change | Var.type | Var.class. | Patients |
|---|
Please mind that curation (inclusion of all reported gene variants) has not started yet. Please contact us if you want to volunteer.
Diagnostic pitfalls & paradigms
Considerations to take into account when analyzing this gene
| Year | Paradigm ⓘ | PMID | Notes |
|---|---|---|---|
| - | Regions of Homology | - | |
| - | Cryptic splicing | - | Unreported or not recorded in our DB. |
| - | Uniparental disomy | - | Unreported or not recorded in our DB. |
| - | Mosaicism | - | Unreported or not recorded in our DB. |
| - | Incomplete penetrance | - | Unreported or not recorded in our DB. |
| - | Di-/oligo-genic inheritance | - | Unreported or not recorded in our DB. |
| - | Somatic reversion | - | Unreported or not recorded in our DB. |
References linked to variants in FPR1
Please mind that curation (inclusion of all relevant literature) has not started yet. Please contact us if you want to volunteer.
| ID | Year | Title | Journal | PMID | Variants |
|---|